Researchers from the University of Cambridge, the National University of Singapore, and A*STAR (Singapore) have developed a clinically defined and translatable hydrogel system using physiological proteins. A base hydrogel, termed “Alphagel”, supported the culture and trilineage differentiation of human pluripotent stem cells (hPSCs) in a three-dimensional environment and demonstrated biocompatibility in vivo. They then engineered a liver-optimised hydrogel, “Hepatogel”, which was shown to improve the retention of hPSC-derived hepatocytes upon direct transplantation into murine livers.
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