skip to primary navigationskip to content

Materials Engineering & Material-Tissue Interactions

Division C - Department of Engineering

Studying at Cambridge

 

Dr Rasha Rezk

Dr Rasha Rezk

Research Fellow

College Lecturer and Bye-Fellow of Gonville & Caius College


Office Phone: +44-(0)1223-762447

Subject groups/Research projects

Brain Cancer Cell Mechanobiology:

Research Interests

My research interests lie in brain cancer cell mechanobiology, combining engineering and cell biology to better understand the relationship between cell adhesion and tumour invasive capacity. Glioblastoma multiforme (GBM) is the most common and malignant primary brain cancer. Life expectancy after diagnosis remains poor despite advances in neurosurgery and subsequent multimodal radio-chemotherapies. GBM exhibits an extensive, rapid and infiltrative growth pattern, which makes it incurable. My projects aims to develop a cell population adhesion test to quantify the role of cell adhesion in regulating GBM migration and tumour infiltration.  I aim to establish how GBM vary in adhesion strength across tumours from different patients, and how this diversity affects cellular responses to treatment (adhesion-targeted therapy). I will apply this to test the efficacy of a novel immunotherapeutic treatment.

Collaborators

Dr Colin Watts (Department of Clinical Neurosciences, Division of Neurosurgery, Addenbrooke's Hospital)

 

Morphological diversity of GBM

Measurement of cell–matrix adhesion dynamics in living glioblastoma cells

Key Publications

J.M. Sobral, T.W. Clyne, R. Rezk, A.E. Markaki, (2017), "Control over Fine Scale Terrace Structures induced on Polycrystalline Pd by Simple Heat Treatments in Air", Surface and Coatings Technology326, Part A, pp. 3

J.M. Sobral, T.W. Clyne, R. Rezk, A.E. Markaki, (2017), "Nano-terracing on Polycrystalline Palladium induced via Simple Heat Treatment", Scripta Materialia130, pp. 17-21. 

J.M. Sobral, V.N. Malheiro, T.W. Clyne, J. Harris, R. Rezk, W. O'Neill, A.E. Markaki, (2016),  "An Accelerated Buoyancy Adhesion Assay combined with 3-D Morphometric Analysis for Assessing Osteoblast Adhesion on Microgrooved Substrata", Journal of the Mechanical Behaviour of Biomedical Materials, 60, pp. 22-37. 

Rezk, R., Srai, J. S., & Williamson, P. J. (2016). The impact of product attributes and emerging technologies on firms’ international configuration. Journal of International Business Studies47(5), pp. 610-618.